{"created":"2024-03-18T08:05:28.835446+00:00","id":2000069,"links":{},"metadata":{"_buckets":{"deposit":"c6f31ff6-7d1c-431c-a08e-a5339716a3b6"},"_deposit":{"created_by":11,"id":"2000069","owners":[11],"pid":{"revision_id":0,"type":"depid","value":"2000069"},"status":"published"},"_oai":{"id":"oai:unii.repo.nii.ac.jp:02000069","sets":["9:10:1709692977390"]},"author_link":[],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-15","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"11","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"人間生活学研究","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Bulletin of Society for Human Life Studies","bibliographic_titleLang":"en"}]}]},"item_2_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ビタミンC（アスコルビン酸）は、ヒトの生体内では作ることができない必須な栄養素である。しかし、脳を含む生体内において、ビタミンC は豊富であるにも関わらず、全身に行き渡される機構については不明な点が多い。特に脳は、血液脳関門に代表されるバリア機構により、水溶性物質の通過が困難であるため、ビタミンC の輸送機構については解明が待たれている。最近、細胞横断型ビタミンC 輸送体の存在が報告された。また、他臓器に比較しても高濃度に維持されているビタミンC の脳における抗酸化性に我々は着目した。我々は、炎症性サイトカイン投与による活性酸素生成に対する抗酸化剤の効果について、主に脂溶性の抗酸化物質を用いて検討をおこなってきたが、本研究においては、サイトカイン誘発性の活性酸素生成に対して、水溶性ビタミンであるL-アスコルビン酸を用いて検討をおこなった。活性酸素種 (ROS : reactive oxygen species)は、生理的状況下において生成され、生体防御のためにも体内でも活発に産生される。しかし、過剰な活性酸素は体内の様々な成分と反応し、細胞を傷害する。我々は、炎症シグナルによって培養神経細胞において誘発される活性酸素に対して、L-アスコルビン酸がどのような影響を与えるか検討をおこない、上皮成長因子、炎症性サイトカインであるインターロイキン-6 および腫瘍壊死因子-α が誘導するROS 産生に対して、弱い、もしくは部分的な減弱効果を及ぼしたことを報告する。","subitem_description_language":"ja","subitem_description_type":"Abstract"},{"subitem_description":"Vitamin C (ascorbic acid) is an essential nutrient that cannot be synthesized in the human body. Although vitaminC is abundant in the body, including the brain, the mechanism by which it is distributed throughout the body is notfully understood. In particular, the brain has barrier mechanisms such as the blood-brain barrier that makes it difficult for water-soluble substances to pass through blood vessel in the brain, so elucidation of the transport mechanism of vitamin C is still awaited. Recently, the existence of a traverse cellular vitamin C transporter has been reported. We therefore focused on the antioxidant effects of vitamin C in the brain, since the brain maintains a relatively high level of vitamin C compared with other organs. We have investigated the production of reactive oxygen species (ROS) by administration of inflammatory cytokines and mainly the effects of fat-soluble antioxidants. In this study, we investigated the inhibition of reactive oxygen species induced by inflammatory cytokines using L-ascorbic acid, a water-soluble vitamin. ROS are produced in physiological conditions and are also actively generated in the body for biological defense. However, excessive ROS cause damage to cellular components in the body. We investigated how L-ascorbic acid affects ROS induced in cultured neurons by inflammatory cytokines, and found that L-ascorbic had either weak or partial effects on ROS production induced by several inflammatory cytokines.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟人間生活学会"}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-8591","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_12":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12585279","subitem_source_identifier_type":"NCID"}]},"item_2_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永野, 忠聖","creatorNameLang":"ja"},{"creatorName":"ナガノ,タダサト","creatorNameLang":"ja-Kana"},{"creatorName":"Nagano, Tadasato","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"砂田, 珠里","creatorNameLang":"ja"},{"creatorName":"スナダ, ジュリ","creatorNameLang":"ja-Kana"},{"creatorName":"Sunada, Juri","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"室橋, 佳澄","creatorNameLang":"ja"},{"creatorName":"ムロハシ, カスミ","creatorNameLang":"ja-Kana"},{"creatorName":"Murohashi, Kasumi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2024-03-22"}],"filename":"nsk_15_11_16.pdf","format":"application/pdf","mimetype":"application/pdf","url":{"url":"https://unii.repo.nii.ac.jp/record/2000069/files/nsk_15_11_16.pdf"},"version_id":"77e86520-e4d5-442d-ac1d-5874edb8909f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ビタミンC","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"培養神経細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"サイトカイン","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"reactive oxygen species","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cultured neuron","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"ascorbic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"培養神経細胞における炎症性サイトカイン誘発性活性酸素に対するビタミンC の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"培養神経細胞における炎症性サイトカイン誘発性活性酸素に対するビタミンC の効果","subitem_title_language":"ja"},{"subitem_title":"Partial Effects of Ascorbic Acid on Cytokine-Induced Oxidation Stress in Cultured Neurons.","subitem_title_language":"en"}]},"item_type_id":"2","owner":"11","path":["1709692977390"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-03-22"},"publish_date":"2024-03-22","publish_status":"0","recid":"2000069","relation_version_is_last":true,"title":["培養神経細胞における炎症性サイトカイン誘発性活性酸素に対するビタミンC の効果"],"weko_creator_id":"11","weko_shared_id":-1},"updated":"2024-03-18T08:05:34.261437+00:00"}