{"created":"2023-05-15T08:13:20.336670+00:00","id":1025,"links":{},"metadata":{"_buckets":{"deposit":"ed1a7f7c-e50c-4232-b826-24805a0ee08e"},"_deposit":{"created_by":12,"id":"1025","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1025"},"status":"published"},"_oai":{"id":"oai:unii.repo.nii.ac.jp:00001025","sets":["9:10:138"]},"author_link":[],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"57","bibliographicPageStart":"49","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"人間生活学研究","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Bulletin of Society for Human Life Studies","bibliographic_titleLang":"en"}]}]},"item_2_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"エンドサイトーシスは、細胞膜が陥入することによって小胞を形成し細胞外から細胞内\nへと物質を取り込む機構である。低分子量G タンパク質Rab5 は、エンドサイトーシスに\n重要な因子であり、GDP が結合した不活性型とGTP が結合した活性型が存在し、この活\n性変化によって高度にエンドサイトーシスが制御されている。ファゴサイトーシスは、エ\nンドサイトーシスの一種であり、マクロファージなどにおいて、生体外から侵入した細菌\nなどの比較的大きな物質を取り込む機構である。筆者らは、ショウジョウバエの\nAntennapedia のホメオドメインに由来する細胞膜透過性ペプチド（Penetratin）とcaveolin-1\nのスキャフォールディングドメイン（SD ドメイン）を融合させた細胞膜透過性caveolin-1\nSD ドメインペプチド（細胞膜透過性CSD ペプチド）が、Rab5 を活性化させファゴサイト\nーシスを促進することを明らかにした。本稿では、カベオラとcaveolin について概説した\n後、細胞膜透過性CSD ペプチドによるファゴサイトーシス促進作用について紹介する。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟人間生活学会"}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-8591","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_12":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12585279","subitem_source_identifier_type":"NCID"}]},"item_2_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"萩原, 真","creatorNameLang":"ja"},{"creatorName":"ハギワラ, マコト","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"松下, 健二","creatorNameLang":"ja"},{"creatorName":"マツシタ, ケンジ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Hagiwara, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsushita, Kenji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-04"}],"displaytype":"detail","filename":"nsk_12_49_57.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nsk_12_49_57.pdf","url":"https://unii.repo.nii.ac.jp/record/1025/files/nsk_12_49_57.pdf"},"version_id":"13b73adf-c260-41bc-9313-12a7e60332ac"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エンドサイトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"ファゴサイトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"カベオラ","subitem_subject_scheme":"Other"},{"subitem_subject":"Rab5","subitem_subject_scheme":"Other"},{"subitem_subject":"caveolin","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞膜透過性ペプチド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"細胞膜透過性caveolin-1 スキャフォールディングドメインペプチドによるファゴサイトーシスの活性化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"細胞膜透過性caveolin-1 スキャフォールディングドメインペプチドによるファゴサイトーシスの活性化","subitem_title_language":"ja"},{"subitem_title":"Activation of phagocytosis by cell-permeable caveolin-1 scaffolding domain peptide","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["138"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-04"},"publish_date":"2021-03-04","publish_status":"0","recid":"1025","relation_version_is_last":true,"title":["細胞膜透過性caveolin-1 スキャフォールディングドメインペプチドによるファゴサイトーシスの活性化"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-19T04:34:49.319932+00:00"}