{"created":"2023-05-15T08:13:20.292634+00:00","id":1024,"links":{},"metadata":{"_buckets":{"deposit":"07bb1142-92aa-48a4-9993-167da5c2e587"},"_deposit":{"created_by":12,"id":"1024","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"1024"},"status":"published"},"_oai":{"id":"oai:unii.repo.nii.ac.jp:00001024","sets":["9:10:138"]},"author_link":[],"item_2_biblio_info_9":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"47","bibliographicPageStart":"39","bibliographicVolumeNumber":"12","bibliographic_titles":[{"bibliographic_title":"人間生活学研究","bibliographic_titleLang":"ja"},{"bibliographic_title":"The Bulletin of Society for Human Life Studies","bibliographic_titleLang":"en"}]}]},"item_2_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_description_6":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Rab タンパク質は、現在までに約60 個同定されており、それぞれが特異的にオルガネラ\nに局在し、細胞内での小胞輸送を制御している。Rab タンパク質は、他の低分子量G タン\nパク質と同様に、GTP が結合した活性型とGDP が結合した不活性型が存在し、分子スイ\nッチとして機能を果たしている。Rab5 は、細胞膜と初期エンドソームに局在するRab タン\nパク質であり、エンドサイトーシスにおける細胞膜からの物質取り込みや小胞輸送、小胞\nと初期エンドソームの融合を制御している。Rab5 の活性はGEF（GDP/GTP 交換因子）、\nGAP（GTPase 促進タンパク質）、Rab GDI（Rab GDP 解離抑制タンパク質）、Rab GDF（Rab\nGDI 解離因子）によって厳密に制御されている。また、活性型Rab5 には様々な因子が相\n互作用し、エンドサイトーシスが進行していくと考えられている。本稿では、最初にRab5\nの活性を制御する因子について触れ、次にRab5 によるクラスリン依存性エンドサイトー\nシスの制御機構について概説する。","subitem_description_language":"ja","subitem_description_type":"Abstract"}]},"item_2_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"新潟人間生活学会"}]},"item_2_source_id_10":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1884-8591","subitem_source_identifier_type":"ISSN"}]},"item_2_source_id_12":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA12585279","subitem_source_identifier_type":"NCID"}]},"item_2_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"萩原, 真","creatorNameLang":"ja"},{"creatorName":"ハギワラ, マコト","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"松下, 健二","creatorNameLang":"ja"},{"creatorName":"マツシタ, ケンジ","creatorNameLang":"ja-Kana"}]},{"creatorNames":[{"creatorName":"Hagiwara, Makoto","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Matsushita, Kenji","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-04"}],"displaytype":"detail","filename":"nsk_12_39_47.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"nsk_12_39_47.pdf","url":"https://unii.repo.nii.ac.jp/record/1024/files/nsk_12_39_47.pdf"},"version_id":"8962325f-7ef2-437a-bac3-b20d3e1cb3dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エンドサイトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"Rab5","subitem_subject_scheme":"Other"},{"subitem_subject":"GEF","subitem_subject_scheme":"Other"},{"subitem_subject":"GAP","subitem_subject_scheme":"Other"},{"subitem_subject":"Rab GDI","subitem_subject_scheme":"Other"},{"subitem_subject":"Rab GDF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"低分子量G タンパク質Rab5 によるエンドサイトーシス制御機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"低分子量G タンパク質Rab5 によるエンドサイトーシス制御機構","subitem_title_language":"ja"},{"subitem_title":"Regulatory mechanism of endocytosis by small GTPase Rab5","subitem_title_language":"en"}]},"item_type_id":"2","owner":"12","path":["138"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-04"},"publish_date":"2021-03-04","publish_status":"0","recid":"1024","relation_version_is_last":true,"title":["低分子量G タンパク質Rab5 によるエンドサイトーシス制御機構"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2023-06-19T04:34:49.025135+00:00"}